41 (a) (b) (c) (d) (e) (f) Proximal wall Distal wall Lumen axis Transformed ROI Adventitial borders LD bordersBinary lumen 42 (g) (h) Fig. 4: Illustrating the algorithmic steps on a single image having curvature. (a) Curved ROI, (b) Lumen axis on ROI, (c) Transformed ROI, (d) Adventitial borders on the transformed ROI, (e) Binary lumen from classifier, (f) LD borders on transformed ROI, (g) LD borders on inverse transformed ROI, (h) LD borders on original ROI. LD bordersLD borders 43 (a) (b) (c) Reader Reader Reader Reader Reader Auto SS Auto SS Auto SST Auto SST Auto SS Auto SST Reader 44 (d) Fig. 5: Carotid Auto LD borders compared against the manual tracings on the grayscale images of four patients for both simple scale-space and transformation based iterative methods. Carotid Auto LD borders are shown in solid white; while manual LD borders are shown in dashed white (Auto SS – Automated Simple scale-space, Auto SST – Automated scale-space with Transformation, Reader – Manual Reader). Reader Auto SS Auto SST Reader 45 (a) (b) (c) (d) Fig. 6: Carotid Auto LD/IAD borders drawn on the gray scale images of patients having jugular vein interference (a) and thick plaque can be seen in (b). (a) Carotid Auto LD borders (solid white) Vs. Manual-1 LD borders (dashed white); (b) Auto LD borders (solid white) Vs. Manual- 2 LD borders (dashed white); (c) Auto IAD borders (solid black) Vs. Manual-1 IAD borders (dashed black); (d) Auto IAD borders (solid black) Vs. Manual-2 IAD borders (dashed black). Auto, LD Borders (solid) Auto, LD Borders (solid) Manual-1, LD Borders (dashed)Manual-1, LD Borders (dashed) Manual-1, IAD Borders (dashed) Auto, IAD Borders (solid) Manual-1, IAD Borders (dashed) Auto, IAD Borders (solid)