The aim of the article is to describe the interregional disparities of tourism accessibility, ie. to evaluate the development of disadvantaged people due to a lack of funds excluded from a certain standard of living. Specifically, it is one of the items of material deprivation. Although the Czech Republic is the region with the lowest level of poverty and people with material deprivation within Europe, there were still many Czech households in 2018 who had a problem financing the weekly vacation during the year. The interregional comparison is based on analyzes of EU-SILC data for the period 2009 to 2018 at the NUTS 2 region level. As the result showed, the most affected group of the unavailability of weekly holidays are households of regions with a high share of unemployment, a high proportion of persons below 60% of the median average wage.