The presented paper deals, in theoretical and conceptual terms, with one of the Smart solutions in the concept of Smart City. A smart solution can be defined as an innovative and functional approach towards solving situations in a responsible way and with positive consequences for society. These smart solutions are the core of the Smart City concept which together with a smart region presents a new economic area where new markets or market segments offering innovative and intelligent (tangible and intangible) solutions for said cities and regions are developed. Specifically, the paper deals with the description of existing and innovative navigation systems in hospital buildings. Emphasis is placed on the analysis and comparison of indirect, explicit effects related to individual ways of navigation in hospitals. Knowledge of these effects, or their monetary quantification, is a key factor in assessing the effectiveness of the innovative solution and thus forms a specific input attribute in the decision-making process on implementation or rejection of such an implementation proposal.