The paper investigates the relationship between the macroeconomic indicators and default rate in the sector of construction and the sector of financial and insurance activities in the Czech Republic. Both long-term and short-term relationships are analysed. This approach requires the construction of vector error correction model which determines both long-term and short-term causal relationship. This investigation is based on the time series of the share of outstanding loans and the total amount of loans, and on selected macroeconomic variables. The results confirm the existence of statistically significant relationships between macroeconomic indicators and the probability of defaults within both sectors. We have used the data from 2005Q1 to 2019Q4. Calculations have been performed by using the Eviews software.