The paper aims to deepen our understanding of the relationship and the impact of creative actors on regional development and investigates the nexus between them. The novelty of the paper lies in constructing an original criteria matrix of creative actors’ indicators which might serve as a basis for further research and policy implications. The original criteria matrix consists of two groups of indicators measuring the creative people and creative capital in the region, their mutual relationships and impact on regional development. We found that creative actors are not distributed equally across the regions in Slovakia. The strong dominance of the region with the capital city (Bratislava) was detected. We also discovered a strong direct positive relationship between representatives of the creative people and a strong direct relationship between the creative people and the emergence of small and medium enterprises (SMEs).