Background: Chronic pancreatitis is a debilitating, progressive and incurable disease, leading to an impaired well-being and affecting quality of life. Aim: To determine the quality of life in patients with chronic pancreatitis. To find out what subjective symptoms are most often perceived by patients, what is their relationship to alcohol before and after the disease and whether they smoke. Set and methods: A quantitative method was used for research purposes, through the use of a standardized WHOQOL-BREF questionnaire. The research group consisted of 70 respondents from gastroenterological clinics. Results: Based on statistical processing, it can be stated that the quality of life is reduced in the physical domain, domains of experiencing and social relationships. Within recommended regime measures, respondents consume alcohol and smoke. Patients do not follow the recommended regimens. Of the subjective symptoms, abdominal pain disturbs the respondents the most. Conclusion: The achieved results confirm the reduced quality of life of patients at the lower limit of the population norm, but the results are not significantly low.