The goal of this article is to investigate the existence and character of the relationship between the Consumer Price Index (CPI) and the Producer Price Index (PPI) for the Czech Republic and Slovakia. Is there a relationship between the CPI and PPI? The CPI-PPI indicator also has a strong correlation with the overall growth rate of the economy. The smaller the difference between CPI-PPI, the higher the operating cost of the enterprise, the lower the profit of the enterprise, the slower growth of the profit of the enterprise, and the slower economic growth. The existence of a long-run equilibrium relationship between CPI and PPI has been tested with the Johansen cointegration. The existence of a long-run equilibrium relationship between CPI and PPI was confirmed in the case of Slovakia. The short-run dynamics were confirmed through statistical methods such as VEC model, Granger causality, and impulse-response function. Granger causality CPI→PPI was confirmed in Slovakia, and the causality PPI→CPI was confirmed in the Czech Republic. The EViews 12 was used for data evaluation. The results are based on the analysis of the data from Eurostat from January 2005 to June 2021 for the Czech Republic and Slovakia.