Abstract Objective: The objective of the work was to find out parents' awareness of safe pharmacotherapy in children. Methodology: A quantitative survey with a non-standardized questionnaire was used to process the work. The research group consisted of parents. Results: Knowledge questions showed that parents have a good knowledge of drug dosing, the importance of drug administration time, including antibiotic treatment, excellent results were in the knowledge of antipyretic drug group and the time interval between doses, but immediately in another question, which also concerned the combination of antipyretics and the time interval, the same number of parents gave interval 4 and 6 hours, which indicated that the parents were not sure of the correct answer in this regard. Parents had insufficient knowledge of the question that determines the temperature at which we administer antipyretics. The larger half answered incorrectly. Furthermore, by sub-objectives, it was discovered that statistical significance was found in the answers between the groups with secondary education without a high school diploma and with university education in the knowledge of safe pharmacotherapy. A significant difference was also found between self-employed parents and unemployed parents, and it was discovered that the number of children also affected parents' knowledge and experience. Conclusion: In many cases, the parent is most often present with the child, especially during the period when the child becomes ill and it is necessary to give the child medication and visit a doctor. For this reason, it would be appropriate to systematically educate parents about the safe administration of medication to children.