Healthcare, like other industries, is increasingly using smart technologies, which also include intelligent/smart wayfinding navigation. The focus of this article, as part of the research project (its second step), was to analyze the economic effectiveness of the introduction of the wayfinding system in a local hospital in the Czech Republic. In the first phase/step of the project, possible variants of the solution were identified, verification of possible functioning, and a questionnaire survey was conducted among employees and patients regarding the waste of time in search of destination and preferences of various forms of navigation. Based on the above, it was decided to develop our own mobile application. To determine the effectiveness of this method of implementation of the new system, economic verification was used by the cost-benefit analysis method. Although the use of this method has not been required in the implementation of funded projects within the European Union since 2021, it was chosen for clarifying the pros and cons in many both investment and non-investment projects. In addition to the net present value calculation, the benefit cost ratio, profitability index, and payback period were used for evaluation. The time saving of medical staff, calculated on the basis of a questionnaire survey in the hospital (the first step of the project), was used as a benefit. The costs used were the salaries paid out in the research project, the investment, and the operating costs over the lifetime of the navigation system, which is estimated at eleven years. Using the above indicators, the implementation of the navigation system was found to be effective, despite the initial high costs.