Další formáty:
BibTeX
LaTeX
RIS
@article{72861, author = {Žatecký, Jan and Coufal, Oldřich and Zapletal, Ondřej and Kubala, Otakar and Kepičová, Markéta and Faridová, Adéla and Rauš, Karel and Gatěk, Jiří and Kosáč, Peter and Peteja, Matúš}, article_number = {1}, doi = {http://dx.doi.org/10.1186/s12957-023-03147-x}, keywords = {Targeted axillary dissection; Breast cancer; Magnetic seed; Iodine seed; Clip; Carbon suspension}, language = {eng}, issn = {1477-7819}, journal = {World Journal of Surgical Oncology}, title = {Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial}, url = {https://wjso.biomedcentral.com/articles/10.1186/s12957-023-03147-x}, volume = {21}, year = {2023} }
TY - JOUR ID - 72861 AU - Žatecký, Jan - Coufal, Oldřich - Zapletal, Ondřej - Kubala, Otakar - Kepičová, Markéta - Faridová, Adéla - Rauš, Karel - Gatěk, Jiří - Kosáč, Peter - Peteja, Matúš PY - 2023 TI - Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial JF - World Journal of Surgical Oncology VL - 21 IS - 1 SP - 250-258 EP - 250-258 SN - 14777819 KW - Targeted axillary dissection KW - Breast cancer KW - Magnetic seed KW - Iodine seed KW - Clip KW - Carbon suspension UR - https://wjso.biomedcentral.com/articles/10.1186/s12957-023-03147-x N2 - BackgroundTargeted axillary dissection (TAD) is an established method for axillary staging in patients with breast cancer after neoadjuvant chemotherapy (NAC). TAD consists of sentinel lymph node biopsy and initially pathological lymph node excision, which must be marked by a reliable marker before NAC.MethodsThe IMTAD study is a prospective multicentre trial comparing three localisation markers for lymph node localisation (clip + iodine seed, magnetic seed, carbon suspension) facilitating subsequent surgical excision in the form of TAD. The primary outcome was to prospectively compare the reliability, accuracy, and safety according to complication rate during marker implantation and detection and marker dislodgement.ResultsOne hundred eighty-nine patients were included in the study-in 135 patients clip + iodine seed was used, in 30 patients magnetic seed and in 24 patients carbon suspension. The complication rate during the marker implantation and detection were not statistically significant between individual markers (p = 0.263; p = 0.117). Marker dislodgement was reported in 4 patients with clip + iodine seed localisation (3.0%), dislodgement did not occur in other localisation methods (p = 0.999). The false-negativity of sentinel lymph node (SLN) was observed in 8 patients, the false-negativity of targeted lymph nodes (TLN) wasn & PRIME;t observed at all, the false-negativity rate (FNR) from the subcohort of ypN + patients for SLN is 9.6% and for TLN 0.0%.ConclusionThe IMTAD study indicated, that clip + iodine seed, magnetic seed and carbon suspension are statistically comparable in terms of complications during marker implantation and detection and marker dislodgement proving their safety, accuracy, and reliability in TAD. The study confirmed, that the FNR of the TLN was lower than the FNR of the SLN proving that the TLN is a better marker for axillary lymph node status after NAC. ER -
ŽATECKÝ, Jan, Oldřich COUFAL, Ondřej ZAPLETAL, Otakar KUBALA, Markéta KEPIČOVÁ, Adéla FARIDOVÁ, Karel RAUŠ, Jiří GATĚK, Peter KOSÁČ a Matúš PETEJA. Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial. \textit{World Journal of Surgical Oncology}. 2023, roč.~21, č.~1, s.~250-258. ISSN~1477-7819. Dostupné z: https://dx.doi.org/10.1186/s12957-023-03147-x.
|