The article shows an overview of the standard functions of the ERP (Enterprise Resource Planning) information system in manufacturing companies and deals with the ERP system data for the optimization of reliability, management and product quality process. A comprehensive approach to data collection, processing and their storage in the ERP system (cloud storage, data warehouses) is necessary for successful management of the production process. By using advanced statistical and artificial intelligence methods (neural networks, trees, logistic regression), it is possible to analyze the data and obtain additional knowledge and dependencies in the data. The application part of the article presents the prediction of reliability indicators. From the ERP system database, the data set of a time to failure has been obtained. This data for the creation of a parametric model, based on Weibull distribution, has been used. The article demonstrates the application of artificial neural networks for the prediction of reliability indicators, and a parametric model based on the Weibull distribution has been created from the input data.