The term SMART is mostly seen and more popular in the sphere of management, where it serves as an analytical technology for projecting the objectives. Lately, the word SMART has been perceived more as an equivalent of the word clever or intelligent in the context of various perceptions, solutions and approaches, and through which we want to accentuate "a distinct, elaborated and complex perspective" through a range of scientific and practical disciplines. SMART attitude is typical for its highly sophisticated analytical methods, attitudes, communications and technologies used for projecting the aims, procedures and planning, and it applies to the entire discipline of transfer of smart solutions into the material and immaterial innovations. In the context of the regional development, the word SMART in its narrow sense is usually connected with the word City, i.e. Smart City, which represents a concept of the developed city based on a sustainable economic development and a quality of life based on efficient utilization of human and social capital and modern information and communication technologies. In this article, the SMART concept will be presented in its broad sense from the perspective of the regional development, the objective being to delimit and identify the regions, elements and processes in which the SMART concept can be appropriately applied and developed in such a way that it promotes a general development in the regions in a positive sense and at the same time, it contributes to the increase of the standards and the quality of life of its population.