The Paper deals with the basic principles of agent and multi-agents modeling in a tourism. The work describes both the basic theoretical definition of the issue of agent and multi-agent systems (MAS) and an overview of current literature in the context of the application of MAS in tourism. The practical part mentions the realization of a simple multi-agent model of the interaction of supply and demand for accommodation in a tourist destination. In the conclusion, there is a conceptual design of a model allowing simulation of supply and demand for accommodation capacities in a tourist destination.