|Although the Czech Republic ranks among the most industrialized countries in Europe, it is not prepared for the coming of technological changes. For a country to take advantage of emerging technologies and the GDP growth and jobs they bring, it must be highly digitalized. Therefore, the chapter is intended to provide the Czech Republic Industry 4.0 approach with the latest issues to the fourth industrial revolution. The chapter aims to point out possible directions of development, to define proposals for measures that can support the economy and industrial base, but also to help prepare the stakeholders from the public and private sector for technological change. Based on a reflection of the current situation, there is a potential development in government support, corporate and stakeholders cooperation approach to principles of the digital transformation that are suitable for implementation to enhance the competitiveness of the Czech Republic. This chapter is based on information gathered through an extensive documents using print media and research databases of European Commission focused on digital economy and society, and we also employed the available Digital Transformation Scoreboard, Digital Transformation monitor, Europe´s digital Progress Report, Digital Index of Roland Berger, and Czech strategic digital transformation documents to systematize a research Agenda of Industry 4.0. The chapter is expected to help in reviewing national digital performance strategies, an overview of the collected outputs may help other entities to the process of digitizing a society efficiently.