Podrobný výpis o publikaci

Autologous transplantation is a process in which the patient's own hematopoietic tissue is transferred. It differs from solid organ transplantation in that it is not a surgical operation. Autologous transplantation consists of several stages: chemotherapy application, mobilisation, haematopoietic cell collection, high-dose chemotherapy, haematopoietic cell transfer and post-transplant care. One of the first phases involves the administration of chemotherapy, which not only has an anti-tumour effect but also a stimulating effect. Then, G-CSF, the so-called growth factors, are administered in the form of s.c. injections, which are necessary for the hematopoietic cell washout. It is often necessary for the patient to inject growth factors in the home environment and therefore education by the attending nurse is essential. The actual collection of the hematopoietic cells is done with a so-called separator. Depending on the amount of stem cells collected, the separation may take 4 hours over several days. Successful collection is followed within a few weeks by the administration of high-dose chemotherapy. Autologous transplantation of the collected hematopoietic cells takes place within 24 hours. The application of hematopoietic cells is the least demanding of the transplantation process. The patient is injected with the prepared cells into a central or peripheral venous inlet. The post-transplant period can be accompanied by various complications. Common complications include nausea, vomiting, mucositis, febrile neutropenia and sepsis. The post-transplant period is the most critical period in terms of strict compliance with hygiene regimes by both staff and patient.